BACKGROUD We used single-marker and novel gene-based methods to examine the
associations of endothelial system genes with blood pressure (BP) changes and …

High blood pressure contributes to more than 10 million deaths per year worldwide through
stroke and ischemic heart disease. Yet, genome-wide association studies (GWASs) have …

We previously selected a group of hypertension candidate genes by a key word search
using the OMIM database of NCBI and validated 525 coding single nucleotide …

Hypertension is a complex multi-factorial and polygenic disorder. Nevertheless, most studies
have focused on single-gene effects. Furthermore, a majority of these studies have been …

In this study, we determined the association of 1180 non-synonymous single-nucleotide
polymorphisms (SNPs) with systolic blood pressure (SBP) and hypertensive status. A total of …

Hypertension is one of the leading risk factors for mortality. The renin–angiotensin–
aldosterone system (RAAS) is a potent and powerful mediator in the homeostasis of …

Although multiple genetic markers associated with blood pressure have been identified by
genome-wide association studies, their aggregate effect on risk of incident hypertension and …

Excessive sodium intake is a global risk factor for hypertension. Sodium effects on blood
pressure vary from person to person; hence, high-risk group targeting based on personal …

Hypertension is a common disorder and one of the most important risk factors for
cardiovascular diseases. The aim of this study was to identify more novel genes for blood …

To obtain evidence for blood pressure (BP) trait association, we conducted an association
study of selected candidate gene variants. In Japan, a total of 19 426 individuals underwent …