[HTML][HTML] Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery

L Volpini, F Monaco, L Santarelli, J Neuzil… - Aspects of Molecular …, 2023 - Elsevier
We are now entering a new era of RNA therapies, such that mRNA-based vaccines and
RNA interference approaches such as siRNA have already been launched on the …

miRNA: the new frontier in cancer medicine

J Ju, J Jiang, A Fesler - Future medicinal chemistry, 2013 - Taylor & Francis
However, it is a difficult task to realize the dream of miRNA-based therapeutics and we are
facing a number of challenges. Challenges, such as stability, toxicity, distribution and …

Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges

P Ubanako, S Mirza, P Ruff, C Penny - Frontiers in Molecular …, 2024 - frontiersin.org
The discovery of novel and innovative therapeutic strategies for cancer treatment and
management remains a major global challenge. Exosomes are endogenous nanoscale …

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

[HTML][HTML] Exosome-derived microRNA: Efficacy in cancer

J Padda, K Khalid, A Khedr, V Patel, OA Al-Ewaidat… - Cureus, 2021 - ncbi.nlm.nih.gov
Exosome-derived microRNA (miRNA) has been the focus of attention in recent years.
Mainly, their role in the pathogenesis of different types of cancer has been extensively …

Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers

R Maheshwari, M Tekade, P Gondaliya, K Kalia… - …, 2017 - Taylor & Francis
RNA interference (RNAi) therapeutics (siRNA, miRNA, etc.) represent an emerging
medicinal remedy for a variety of ailments. However, their low serum stability and low …

Exosome as a target for cancer treatment

S Nafar, N Nouri, M Alipour, J Fallahi… - Journal of …, 2022 - journals.sagepub.com
Exosomes are small vesicles covered by a lipid bilayer, ranging in size from 50 nm to 90 nm,
secreted by different cell types in the body under normal and pathological conditions. They …

Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors

C Lässer - Expert opinion on biological therapy, 2012 - Taylor & Francis
Introduction: Exosomes are nano-sized (40–100 nm), extracellular vesicles, of endosomal
origin. They are released by cells and found in many body fluids, including plasma …

[HTML][HTML] Exosomes and other extracellular vesicles-mediated microRNA delivery for cancer therapy

G Di Rocco, S Baldari, G Toietta - Translational Cancer Research, 2017 - tcr.amegroups.org
Extracellular vesicles (EVs), including exosomes and microvesicles, are critical mediators of
cell-to-cell communication in tissue homeostasis and repair, both in physiological and …

Expression, regulation, and function of exosome‐derived miRNAs in cancer progression and therapy

B Li, Y Cao, M Sun, H Feng - The FASEB Journal, 2021 - Wiley Online Library
Exosomes are a novel class of intercellular signal modulators that contain a wide range of
molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type …