Activation of vascular endothelial growth factor receptor‐1 and‐2 (VEGFR‐1 and VEGFR‐2)
plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which …

Vascular endothelial growth factor receptor-2 (VEGFR-2/FLK-1) is a receptor tyrosine kinase
whose activation stimulates angiogenesis. We recently generated a chimeric VEGFR-2 in …

VEGFR-1 is devoid of ligand-dependent tyrosine autophosphorylation and its activation is
not associated with proliferation of endothelial cells. The molecular mechanism responsible …

Angiogenesis involves endothelial cell differentiation, proliferation, migration and cord
formation, which lead to tubulogenesis to form vessels. One group of growth factor receptors …

Vascular endothelial growth factor (VEGF) provokes angiogenesis in vivo and stimulates
growth and differentiation of endothelial cells in vitro. Although VEGF receptor-1 (VEGFR-1) …

Although VEGFR-3 deficiency disrupts blood vascular development during early
embryogenesis, the underlying mechanism was not clear. To characterize its function in …

Vascular endothelial growth factors (VEGFs) and their receptors play key roles in
angiogenesis and lymphangiogenesis. VEGF activates VEGF receptor-1 (VEGFR-1) and …

Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in
vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation …

VEGFR-3 is essential for vascular development and maintenance of lymphatic vessel's
integrity. Little is known about its cooperative effect with other receptors of the same family …

VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate
the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and …