Accumulated evidence suggests the involvement of vascular factors in late-onset
depression. Late-onset depression has characteristics of poor outcome, cognitive decline …

Aim: Functional neuroimaging studies to date have indicated prefrontal dysfunction in late‐
onset major depression (LOD). The relationships between prefrontal dysfunction and clinical …

The present study investigated functional changes of brain oxygenation in prefrontal brain
areas of nine depressed patients and nine age-and sex-matched healthy comparison …

Aims Near‐infrared spectroscopy has the potential for aiding the diagnosis of major
depressive disorder. The purpose of this study was to systematically review the evidence …

Background Previous functional neuroimaging studies of depression have demonstrated
frontotemporal dysfunction, including the dorsolateral prefrontal cortex, while patients …

Objectives: Evidence is mounting linking cerebrovascular disease with the development of
major depression in the elderly. Lesions in both white and gray matter have been associated …

The aim of this study was to determine whether melancholia differs from nonmelancholic
depression in frontotemporal functioning by means of multichannel near-infrared …

Background. Hypofrontality has been demonstrated in mood disorders by functional brain
imaging methods such as positron emission tomography. However, the neurobiological …

The activation of oxygenated hemoglobin (oxy-Hb) has been shown to be lacking in the
prefrontal cortex (PFC) of patients with late-onset depression (LOD), in verbal fluency task …

Objective: This study tests whether or not the structural white matter lesions that are
characteristic of late-life depression are associated with alterations in the functional affective …