For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Investigative toxicology describes the de-risking and mechanistic elucidation of toxicities,
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …

Recent high-profile drug withdrawals increase the pressure on regulators and the
pharmaceutical industry to improve preclinical safety testing. Understanding mechanisms of …

Toxicity is a leading cause of attrition at all stages of the drug development process. The
majority of safety-related attrition occurs preclinically, suggesting that approaches to …

A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for
toxicologists in industry and regulatory settings, as well as directors working in contract …

Attrition due to nonclinical safety represents a major issue for the productivity of
pharmaceutical research and development (R&D) organizations, especially during the …

Mechanistic toxicology has evolved by relying, to a large extent, on methodologies that
substitute or complement traditional animal tests. The biotechnology and informatics …

Highlights•Early hazard identification, reliable risk assessment and diligent risk avoidance
strategies are essential.•We describe why toxicology should be an integrated discipline …

A clear, straightforward resource to guide you through preclinical drug development
Following this book's step-by-step guidance, you can successfully initiate and complete …

Acting on reports in the late 1980s that most drug candidates fail in development,
pharmaceutical discovery programmes responded by devising ways to increase the number …