Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …
GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …
somatosensory domain. This conceptualization is problematic because, unlike most other …
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
B Costa, AE Trovato, F Comelli, G Giagnoni… - European journal of …, 2007 - Elsevier
Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
inflammatory and immunomodulatory effects. This study investigated its therapeutic potential …
Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model
CHA Jesus, MV Ferreira, AT Gasparin, ES Rosa… - Behavioural Brain …, 2022 - Elsevier
Neuropathic pain (NP) is a complex health problem that includes sensorial manifestations
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model
A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
Cannabidiol for pain treatment: focus on pharmacology and mechanism of action
J Mlost, M Bryk, K Starowicz - International journal of molecular sciences, 2020 - mdpi.com
Cannabis has a long history of medical use. Although there are many cannabinoids present
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two …
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial …
RB Malvestio, P Medeiros, SE Negrini-Ferrari… - Brain Research …, 2021 - Elsevier
The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …
is putatively implicated in the chronic pain and depression. We investigated the activity of …
Cannabis constituent synergy in a mouse neuropathic pain model
SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …
against neuropathic pain, however, this is hampered by their side effects. It has been …
[HTML][HTML] Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors
CHA Jesus, DDB Redivo, AT Gasparin, BB Sotomaior… - Brain research, 2019 - Elsevier
Most diabetic patients describe moderate to severe pain symptoms whose pharmacological
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …