The ɑ/ß T cell receptor (TCR) recognizes peptide fragments bound in the groove of major
histocompatibility complex (MHC) molecules. We modified the TCR ɑ chain from a mouse T …

The α/β T cell receptor (TCR) recognizes peptide fragments bound in the groove of major
histocompatibility complex (MHC) molecules. We modified the TCR α chain from a mouse T …

T cells recognize MHC-bound peptide, suggesting that the TCR contacts surface MHC
residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also …

We determined the crystal structures of the T cell receptor (TCR)-like antibody 25-D1. 16 Fab
fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K b molecule …

Recent results have added new information to our understanding of a~ 8 T-cell receptor
mediated recognition. In particular, we find that the V (D) J junction or'CDR3'portion of TCRa …

The TCR is predicted to resemble the Fab fragment of an Ig molecule and by analogy to
possess six Ag binding loops that contact MHC proteins bound with antigenic peptides. We …

Significant progress has been made on several long-standing issues regarding T-cell
receptor mediated recognition of antigen-MHC complexes. For one, early data suggest that …

The ligands for alpha beta T cell receptors (αβTCRs) are usually major histocompatibility
complex (MHC) proteins bound to peptides. Although there is evidence that T cell receptor …

We have identified residues on a T cell receptor (TCR) alpha chain that are important for
interaction with antigen/major histocompatibility complex (MHC). Using site-directed …

We review recent data that increase our understanding of the ternary complex of the T cell
receptor (TCR), antigenic peptides, and molecules of the major histocompatibility complex …