Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian …

K Wojciech, MA Milad, AH Jobe… - Journal of …, 2021 - search.proquest.com
Population pharmacokinetic/pharmacodynamic (PK/PD) analysis was performed for
extensive data for differing dosage forms and routes for dexamethasone (DEX) and …

Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian …

W Krzyzanski, MA Milad, AH Jobe, T Peppard… - … of Pharmacokinetics and …, 2021 - Springer
Population pharmacokinetic/pharmacodynamic (PK/PD) analysis was performed for
extensive data for differing dosage forms and routes for dexamethasone (DEX) and …

Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women

W Krzyzanski, MA Milad, AH Jobe, T Peppard… - … of Pharmacokinetics and …, 2021 - Springer
Population analysis of pharmacokinetic data for five differing dosage forms and routes for
dexamethasone and betamethasone in 48 healthy nonpregnant Indian women was …

Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women

K Wojciech, MA Milad, AH Jobe… - Journal of …, 2021 - search.proquest.com
Population analysis of pharmacokinetic data for five differing dosage forms and routes for
dexamethasone and betamethasone in 48 healthy nonpregnant Indian women was …

Pharmacokinetics and pharmacodynamics of intramuscular and oral betamethasone and dexamethasone in reproductive age women in India

AH Jobe, MA Milad, T Peppard… - Clinical and …, 2020 - Wiley Online Library
High‐dose betamethasone and dexamethasone are standard of care treatments for women
at risk of preterm delivery to improve neonatal respiratory and mortality outcomes. The dose …

Across‐species meta‐analysis of dexamethasone pharmacokinetics utilizing allometric and scaling modeling approaches

D Song, WJ Jusko - Biopharmaceutics & drug disposition, 2021 - Wiley Online Library
The pharmacokinetic (PK) parameters of dexamethasone (DEX) in 11 species were
collected from the literature and clearances (CL) assessed by basic allometric methods, and …

Minimal physiologically‐based hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids

W Krzyzanski, MA Milad, AH Jobe… - CPT: Pharmacometrics …, 2023 - Wiley Online Library
Minimal physiologically‐based pharmacokinetic (mPBPK) models are an alternative to full
physiologically‐based pharmacokinetic (PBPK) models as they offer reduced complexity …

Physiologically based pharmacokinetics of dexamethasone in rats

D Song, L Sun, DC DuBois, RR Almon, S Meng… - Drug Metabolism and …, 2020 - ASPET
Blood and multitissue concentration-time profiles for dexamethasone (DEX), a synthetic
corticosteroid, were measured in male rats after subcutaneous bolus and infusion dosing. A …

Development of physiologically based pharmacokinetic/pharmacodynamic model for indomethacin disposition in pregnancy

S Alqahtani, A Kaddoumi - PloS one, 2015 - journals.plos.org
Findings of a recent clinical study showed indomethacin has lower plasma levels and higher
steady-state apparent clearance in pregnant subjects when compared to those in non …

Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats

MN Samtani, M Schwab, PW Nathanielsz… - Pharmaceutical …, 2004 - Springer
No Heading Purpose. The pharmacokinetics of corticosteroids in pregnancy were analyzed
to assess maternal/fetal disposition and factors controlling fetal exposure. Area/Moment …