As lysosomal hydrolysis has long been suggested to be responsible for myelin clearance
after peripheral nerve injury, in this study, we investigated the possible role of …

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide
range of conditions that cause disease or injury to peripheral nerves, the cellular and …

Peripheral nerve myelination involves dynamic changes in Schwann cell morphology and
membrane structure. Recent studies have demonstrated that autophagy regulates organelle …

The ubiquitin‐proteasome system (UPS), lysosomes, and autophagy are essential protein
degradation systems for the regulation of a variety of cellular physiological events including …

Emerging lines of evidence show that the mechanisms of neurite degeneration are
convergent, with poor neuritic transport, mitochondrial dysfunction and an increase in intra …

Schwann cells (SCs), which form the peripheral myelin sheath, have the unique ability to
dedifferentiate and to destroy the myelin sheath under various demyelination conditions …

Autophagy is the cellular process involved in transportation and degradation of membrane,
proteins, pathogens, and organelles. This fundamental cellular process is vital in …

Axonal degeneration is one of the initial steps in many neurological disorders and has been
associated with increased autophagic activity. Although there are increasing data on the …

Degeneration of axons and dendrites is a common and early pathological feature of many
neurodegenerative disorders, and is thought to be regulated by mechanisms distinct from …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …