The disproportionate evolutionary expansion of the human cerebral cortex with
reinforcement of cholinergic innervations warranted a major rise in the functional and …

The enormous, 2–3-million-year evolutionary expansion of hominin neocortices to the
current enormity enabled humans to take over the planet. However, there appears to have …

The traditional approach in medicine is to define diseases phenotypically based on clinically
demonstrable signs and symptoms. When our understanding of the nervous system was …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens (Apostolova …

Alzheimer's disease (AD) is neuropathologically characterized by neuritic plaques and
neurofibrillary tangles. Progression of both plaques and tangles throughout the brain follows …

Background: Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder with interrelated molecular, physiological, anatomical …

Age is the major demographic risk factor for the development of Alzheimer's disease (AD)
and the ageing of our society has contributed to the growing importance of AD. The problem …

Alzheimer′ s disease (AD) is a neurodegenerative disorder of higher age that specifically
occurs in human. Its clinical phase, characterized by a decline in physiological …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by fibrillary
aggregates of Aβ peptide and tau protein. The distribution of these pathological hallmarks …

The link between histopathological hallmarks of Alzheimer's disease (AD), ie amyloid
plaques, and neurofibrillary tangles, and AD-associated cognitive impairment, has long …