THE PAST two decades have brought extraordinary progress in the understanding of
Alzheimer disease (AD). The era was ushered in by the discovery of the relatively selective …

Background Both neurodegeneration of the cholinergic basal forebrain (BF) and deposition
of β‐amyloid are early events in the course of Alzheimer's disease (AD). Associations …

The pathogenetic events that lead to Alzheimer's disease (AD) are not fully understood,
although the current knowledge of the pathological changes that occur in AD suggests that …

Toward a holistic model of Alzheimer’s | Science news careers commentary Journals Science
Science brought to you byGoogle Indexer Log in science science advances science immunology …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Katherine L. Bick and Sangram S. Sisodia. oxidative stress as disease-causing
mechanisms. The final 1999. Philadelphia: Lippincott Williams & Wilkins. two chapters report …

Alzheimer's disease, the most common neurodegenerative disorder of senile dementia, is
characterized by two major morpho-pathological hallmarks. Deposition of extracellular …

Although the two pathological hallmarks of Alzheimer's disease (AD), senile plaques
composed of amyloid-β (Aβ) peptides and neurofibrillary tangles (NFTs) consisting of …

While a handful of neurotransmitter systems including cholinergic, norepinephrinergic, and
serotonergic undergo significant degeneration in Alzheimer's disease, the cholinergic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with typical
neuropathological hallmarks, such as neuritic plaques and neurofibrillary tangles …