Homologous recombination (HR) is a major, conserved pathway of chromosome damage
repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA …

Homologous recombination (HR) provides an important mechanism to repair both
accidental and programmed DNA double-strand breaks (DSBs) during mitosis and meiosis …

Homologous recombination (HR) is highly relevant to cancer intervention for two major
reasons. First, defects or deregulation in HR systems are major contributing factors in …

Homologous recombination (HR) comprises a series of interrelated pathways that function in
the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In …

The DNA double-strand break (DSB), arising from exposure to ionizing radiation or various
chemotherapeutic agents or from replication fork collapse, is among the most dangerous of …

To cope with DNA damage, cells possess a complex signaling network called the 'DNA
damage response', which coordinates cell cycle control with DNA repair. The importance of …

Homologous recombination (HR) is essential for accurate genome duplication and
maintenance of genome stability. In eukaryotes, chromosomal double strand breaks (DSBs) …

Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous
chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead …

Homologous recombination (HR) is essential for cellular survival in mammals. In this review,
the substrates for HR, the pathways of repair, and their end products (ie sister chromatid …

Homologous recombination (HR) is a conserved mechanism that repairs broken
chromosomes via intact homologous sequences. How different genomic, chromatin and …