Delayed cerebral ischemia (DCI) continues to be a sequela of aneurysmal subarachnoid
hemorrhage (aSAH) that carries significant morbidity and mortality. Aside from nimodipine …

Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in
patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for …

Background Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) has
been linked to focal reductions in cerebral blood flow (CBF) and microvascular impairments …

Hemorrhagic strokes such as intracerebral hemorrhage (ICH) and subarachnoid
hemorrhage (SAH) are common diseases, but their effective treatments are limited. As a …

Objectives: Impaired oxygen delivery due to reduced cerebral blood flow is the hallmark of
delayed cerebral ischemia following subarachnoid hemorrhage. Since anemia reduces …

Background Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the
occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …

Delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH) is a
major cause of mortality and morbidity. The pathophysiology of DCI after aSAH is thought to …

Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

Introduction Preclinical studies provided a strong rationale for a pathophysiological link
between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain …