OBJECTIVE: It has been proposed that delayed ischemic neurological deficits are induced
by red blood cell (RBC) products after subarachnoid hemorrhage. Prophylactic treatment …

Background and Purpose—S-nitrosylated hemoglobin (S-nitrosohemoglobin) has been
implicated in the delivery of O2 to tissues through the regulation of microvascular blood flow …

Background Although blood transfusions can be lifesaving in severe hemorrhage, they can
also have potential complications. As anemia has also been associated with poor outcomes …

Background: After aneurysmal subarachnoid hemorrhage (SAH), thrombus forms over the
cerebral cortex and releases hemoglobin. When extracellular, hemoglobin is toxic to …

Subarachnoid hemorrhage (SAH) affects 30,000 people in the Unites States alone each
year. Delayed cerebral ischemia occurs days after subarachnoid hemorrhage and …

Both severe anemia and red blood-cell transfusion may negatively influence clinical
outcome in neurocritical patients. Acceptance of low hemoglobin concentrations may be …

Background and Purpose—Red blood cell (RBC) lysis contributes to brain edema formation
after intracerebral hemorrhage (ICH), and RBC hemolysate (oxyhemoglobin) has been …

Despite improvements in the clinical management of aneurysmal subarachnoid
haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single …

Background and Purpose—The PILLAR (Extracorporeal Filtration of Subarachnoid
Hemorrhage via Spinal Catheter) study is a first-in-human trial of cerebrospinal fluid (CSF) …

Early brain injury (EBI) has become an area of extreme interest in the recent years and
seems to be a common denominator in the pathophysiology of global transient ischemia and …