Many natural products have been so far tested regarding their potency to inhibit vascular
smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary …

Cardiovascular diseases are a major cause of human death worldwide. Excessive
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …

Natural products are used widely for preventing intimal hyperplasia (IH), a common
cardiovascular disease. Four different cells initiate and progress IH, namely, vascular …

Excessive proliferation of vascular smooth muscle cells (VSMCs) contributes to the
pathogenesis of many cardiovascular diseases, including atherosclerosis and pulmonary …

Abstract The Holy Grail of cardiovascular pharmacology has been the search for an effective
therapy targeting restenosis after angioplasty and/or intra-arterial stenting. The failure of …

Microvessels are an integral component of the neointima developing in response to the
acute vascular injury resulting from angioplasty. These vessels originate from the vasa …

Atherosclerosis is the principal cause of myocardial infarction, stroke, and peripheral
vascular disease, accounting for nearly half of all mortality in developed countries. For …

Angiogenesis is the natural and physiologic process of growing blood vessels from pre-
existing ones. Pathological angiogenesis occurs when the precise balance of all the …

Intimal hyperplasia is the cause of the recurrent occlusive vascular disease (restenosis).
Drugs currently used to treat restenosis effectively inhibit smooth muscle cell (SMC) …

Local strategies directed against vascular smooth muscle cell (VSMC) proliferation such as
drug-eluting stents reduce the occurrence of restenosis. However, these approaches may …