Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility
Genome-wide association studies (GWAS) have identified hundreds of loci associated with
Crohns disease (CD), however, as with all complex diseases, deriving pathogenic …
Crohns disease (CD), however, as with all complex diseases, deriving pathogenic …
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …
The quest for genetic risk factors for Crohn's disease in the post-GWAS era
Multiple genome-wide association studies (GWASs) and two large scale meta-analyses
have been performed for Crohn's disease and have identified 71 susceptibility loci. These …
have been performed for Crohn's disease and have identified 71 susceptibility loci. These …
Genome-wide association studies and Crohn's disease
The development of genome-wide association scanning (GWAS) has revolutionized the
search for genetic loci associated with complex diseases. Crohn's disease (CD), together …
search for genetic loci associated with complex diseases. Crohn's disease (CD), together …
Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants
Objective Genome wide association studies (GWAS) and meta-analyses for Crohn's disease
(CD) have not fully explained the heritability of CD, suggesting that additional loci are yet to …
(CD) have not fully explained the heritability of CD, suggesting that additional loci are yet to …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study
Background & Aims Crohn's disease is a highly heterogeneous inflammatory bowel disease
comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have …
comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have …
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal
microbiota with the host immune system in genetically susceptible individuals. The largest …
microbiota with the host immune system in genetically susceptible individuals. The largest …
Genome‐wide association studies in Crohn's disease: past, present and future
B Verstockt, KGC Smith, JC Lee - Clinical & translational …, 2018 - Wiley Online Library
Over the course of the past decade, genome‐wide association studies (GWAS) have
revolutionised our understanding of complex disease genetics. One of the diseases that has …
revolutionised our understanding of complex disease genetics. One of the diseases that has …
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
JV Raelson, RD Little, A Ruether… - Proceedings of the …, 2007 - National Acad Sciences
Genome-wide association (GWA) studies offer a powerful unbiased method for the
identification of multiple susceptibility genes for complex diseases. Here we report the …
identification of multiple susceptibility genes for complex diseases. Here we report the …