Thrombotic diseases are a major cause of death and morbidity. Factor Xa (fXa) plays a vital
role in the regulation of normal homeostasis and abnormal intravascular thrombus …

Compound YM-60828 was previously characterized in our laboratory as a potent, selective
and orally-bioavailable Factor Xa (FXa) inhibitor. The L-shape conformation of this …

Since Factor Xa (FXa) is well known to play a central role in thrombosis and hemostasis,
inhibition of FXa is an attractive target for antithrombotic strategies. As a part of our …

Thrombosis is a major cause of mortality in the industrialized world. Therefore, the control of
blood coagulation has become a major target for new therapeutic agents. One attractive …

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing
effective and safe anticoagulants. Although a large number of FXa inhibitors have been …

An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally
modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid …

Factor Xa (FXa) is a serine protease which plays a pivotal role in the coagulation cascade.
The inhibition of FXa has received great interest as a potential target for the development of …

Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …

Since factor Xa (fXa) plays a pivotal role in the blood coagulation cascade, inhibition of fXa
is thought to be an effective treatment for a variety of thrombotic events.(2S)-2-[4-[[(3S)-1 …

To enhance the potency of 1, 2-dibenzamidobenzene-derived inhibitors of factor Xa (fXa),
an amidine substituent was incorporated on one of the benzoyl side chains to interact with …