Factor Xa (fXa) is a key enzyme in the coagulation cascade and an essential component of
the prothrombinase complex, which activates prothrombin to thrombin, leading to fibrin clot …

Factor Xa (fXa) is a serine protease that plays a pivotal role in the coagulation cascade. High-
throughput screening of the Yamanouchi compound library yielded lead compound 1 with …

Thrombosis is a major cause of mortality in the industrialized world. Therefore, the
prevention of blood coagulation has become a major target for new therapeutic agents. One …

Background: Factor Xa (FXa) has been a target of considerable interest for drug
development efforts aimed at suppressing thrombosis. In this report, a new orally active …

As part of an ongoing effort to prepare orally active factor Xa inhibitors using structure-based
drug design techniques and molecular recognition principles, a systematic study has been …

Factor Xa (fXa) is an important serine protease that holds the central position linking the
intrinsic and extrinsic activation mechanisms in the blood coagulation cascade. Therefore …

Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of
new anticoagulant agents. We previously reported the imidazo [1, 5-c] imidazol-3-one …

Intravascular clot formation is an important factor in a number of cardiovascular diseases.
Therefore, the prevention of blood coagulation has become a major target for new …

Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation
linking the intrinsic and extrinsic pathways to the final common pathway of the coagulation …

Two conformationally constrained templates have been designed to provide selective
inhibitors of the coagulation cascade serine protease, Factor Xa (FXa). The most active …