Rheumatoid arthritis is a chronic systemic inflammatory disease primarily affecting the
synovium of diarthrodial joints. Despite the currently unknown etiology, overwhelming …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown
aetiology, leading to progressive damage of bone and cartilage with functional impairment …

Events that occur in rheumatoid arthritis synovial tissues are responsible for the signs and
symptoms of joint inflammation and for the eventual destruction of articular and periarticular …

There is little doubt that the immune system plays an integral role in the pathogenesis of
rheumatoid arthritis. However, the contributions of various cell types, including lymphocytes …

Background Osteoarthritis (OA) affects the entire joint, initially with a low degree of
inflammation. Synovitis is correlated with the severity of OA clinical symptoms and cartilage …

Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Objectives Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease of
unknown aetiology. Recent work has shown that systemic autoimmunity precedes synovial …

Chronic inflammation is characterized by the accumulation of leucocytes within tissues. In
rheumatoid arthritis the inflammatory infiltrate shares many architectural features with …

Genetic, environmental, and epigenetic factors simultaneously or serially contribute to
immune cells and resident joint tissue cell abnormalities, invariably leading to joint …

Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …