Background: In children, a large variability in pharmacokinetics of midazolam, a cytochrome
P450 3A4/5 (CYP3A4/5) enzyme substrate, has been described, which cannot be explained …

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐
metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to …

Interventions The pharmacokinetics of midazolam and metabolites were determined during
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …

Objectives To determine the extent of inter-individual variation in clearance of midazolam in
children and establish which factors are responsible for this variation. Methods A systematic …

Aims Inflammation and organ failure have been reported to have an impact on cytochrome
P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to …

Rationale: Various in vitro, animal, and limited human adult studies suggest a profound
inhibitory effect of inflammation and disease on cytochrome P-450 3A (CYP3A)-mediated …

Background and objective Major changes in cytochrome P450 (CYP) 3A activity may be
expected in the first few months of life with, later, relatively limited changes. In this analysis …

Purpose Changes in drug absorption and first-pass metabolism have been reported
throughout the pediatric age range. Our aim is to characterize both intestinal and hepatic …

Altered physiology caused by critical illness may change midazolam pharmacokinetics and
thereby result in adverse reactions and outcomes in this vulnerable patient population. This …

OBJECTIVE: To determine the steady-state plasma concentrations of midazolam in critically
ill infants and children. DESIGN: Prospective uncontrolled study conducted over 18 months …