Background Chronotherapy (sleep deprivation, sleep phase shifting and/or the use of bright
light) combines non-invasive and non-pharmacological interventions that may act rapidly …

Background Given the strong relationship between circadian rhythm disruption and mood
regulation, combined chronotherapeutic approaches have been proposed for mood …

BACKGROUND: Most antidepressant medications in current use have several
disadvantages: a delayed therapeutic effect, side effects, stigmatization and concerns about …

Objective As part of a series of papers ['Chronobiology of mood disorders' Malhi & Kuiper.
Acta Psychiatr Scand 2013; 128 (Suppl. 444): 2–15; and 'It's time we managed depression …

Depressive syndromes are frequent and heterogeneous brain conditions with more than
90% of patients suffering from sleep complaints. Better characterizing this “sleep” domain …

The global prevalence of depression is increasing, along with rates of depression-
associated disability and mortality, rendering depressive disorders a major public health …

Background There are a dozen studies on double or triple chronotherapy in depression
(sleep deprivation [wake therapy]+ light therapy+ sleep advance/stabilization). We …

Depression is a significant public health issue, made worse by the absence of response to
antidepressant medications by many patients. Given the high degree of overlap between …

Chronotherapeutics–treatments based on the principles of circadian rhythm organization
and sleep physiology–offers mental health practitioners a set of nonpharmaceutical, rapid …

Background The combination of sleep deprivation and light therapy, called combined
chronotherapy, may yield positive short-and long-term results, even in patients with …