Objective To examine the efficacy of using wake and light therapy as a supplement to
standard treatment of hospitalized patients with depression. Method In this randomized …

Background Expanding our understanding of the factors that influence depression is crucial
for prognosis and treatment. In light of increasing evidence of an association between …

Context Major depressive disorder (MDD) in elderly individuals is prevalent and debilitating.
It is accompanied by circadian rhythm disturbances associated with impaired functioning of …

Background Clinical psychiatry has always been limited by the lack of objective tests to
substantiate diagnoses and a lack of specific treatments that target underlying …

Background Despite advances in the treatment of depression, one-third of depressed
patients fail to respond to conventional antidepressant medication. There is a need for more …

There is an urgent need for rapid, effective, and safe treatments for bipolar depression.
Triple chronotherapy is a combination of sleep deprivation, sleep phase advance, and bright …

Background: Bright light therapy (BLT) has been used as a treatment for seasonal affective
disorder (SAD) for over 30 years. This meta-analysis was aimed to assess the efficacy of …

The clinical observations of diurnal variation of mood and early morning awakening in
depression have been incorporated into established diagnostic systems, as has the …

Introduction Major depressive disorder is one of the most commonly diagnosed psychiatric
illnesses, and it has a profound negative impact on an individual's ability to function. Up to …

Background According to the phase-shift hypothesis for winter depression, morning light
(which causes a circadian phase advance) should be more antidepressant than evening …