Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

In the June 1992 edition of the Journal of Clinical Oncology, Myers el al.(1) reported on 38
cases of metastatic hormone refractory pros tate cancer treated with suramin, a bis …

Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat
African river blindness and African sleeping sickness. Suramin has also been extensively …

The concept of disease-specific chemotherapy was developed a century ago. Dyes and
arsenical compounds that displayed selectivity against trypanosomes were central to this …

Protein-tyrosine phosphatases (PTPs) are important signaling enzymes that have emerged
within the last decade as a new class of drug targets. It has previously been shown that …

Suramin, a polyanionic naphthylurea, represents a novel class of antineoplastic drugs with a
variety of activities against tumor cell proliferation. However, its clinical use is hampered by …

Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and
diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping …

Hydrogen sulfide (H2S) has gained significant attention as a potent bioregulator in the redox
metabolome, but it is just one of many reactive sulfur species (RSS). Recently, small …

African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited
treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely …

Since the publication of our previous Perspective dealing with polyamine drug discovery, 1
the field has undergone numerous changes. Most prominent among these changes, from a …