[HTML][HTML] Spinal cord injury sequelae alter drug pharmacokinetics: an overview

H Mestre, T Alkon, S Salazar, A Ibarra - Spinal cord, 2011 - nature.com
Study design: Literature review. Objectives: Critical review of the literature published on the
physiological alterations caused by spinal cord injury (SCI) and their effect on the …

Clinical pharmacokinetics in patients with spinal cord injuries

JL Segal, SR Brunnemann - Clinical pharmacokinetics, 1989 - Springer
Although spinal cord injury is a catastrophic affliction with numerous victims and a variety of
physiological manifestations, the associated disarray in physiology has yet to be …

[HTML][HTML] Acute spinal cord injury changes the disposition of some, but not all drugs given intravenously

P García-López, A Martínez-Cruz, G Guízar-Sahagún… - Spinal cord, 2007 - nature.com
Study design: Experimental laboratory investigations in paraplegic rats. Objective: In order to
understand why acute spinal cord injury (SCI) changes the disposition of some, but not all …

Pharmacological management of secondary spinal cord injury

A Baroncini, N Maffulli, J Eschweiler… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Secondary spinal cord injury (SCI) sets on immediately after trauma and,
despite prompt treatment, may become chronic. SCI is a complex condition and presents …

Optimal drug therapy and therapeutic drug monitoring after spinal cord injury: a population-specific approach

JL Segal, MS Pathak - American Journal of Therapeutics, 2001 - journals.lww.com
Survival after spinal cord injury (SCI), once measured in terms of weeks or months, is now
measured in years, and most survivors of SCI go on to live full lives. The quality of life …

New perspectives for the treatment options in spinal cord injury

HS Sharma - Expert Opinion on Pharmacotherapy, 2008 - Taylor & Francis
Spinal cord injury (SCI) is a serious clinical disorder that leads to lifetime disability for which
no suitable therapeutic agents are available so far. Further research is needed to …

Acute spinal cord injury, part I: pathophysiologic mechanisms

RJ Dumont, DO Okonkwo, S Verma… - Clinical …, 2001 - journals.lww.com
Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound
influences on modern society from physical, psychosocial, and socioeconomic perspectives …

Spinal cord injury pharmacotherapy: Current research & development and competitive commercial landscape as of 2015

JR Guercio, JE Kralic, EJ Marrotte… - The Journal of Spinal …, 2019 - Taylor & Francis
Context Current treatment of spinal cord injury (SCI) focuses on cord stabilization to prevent
further injury, rehabilitation, management of non-motor symptoms, and prevention of …

Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II

N Nagoshi, MG Fehlings - Expert opinion on investigational drugs, 2015 - Taylor & Francis
Introduction: Efforts in basic research have clarified mechanisms involved in spinal cord
injury (SCI), and resulted in positive findings using experimental treatments including cell …

Pharmacological approaches to chronic spinal cord injury

I Steuer, P Rouleau, PA Guertin - Current pharmaceutical …, 2013 - ingentaconnect.com
Although research on neural tissue repair has made enormous progress in recent years,
spinal cord injury remains a devastating condition for which there is still no cure. In fact …