Racial and ethnic differences in multigene hereditary cancer panel test results for women with breast cancer
To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …
Comparison of the prevalence of pathogenic variants in cancer susceptibility genes in black women and non-hispanic white women with breast cancer in the United …
Importance The prevalence of germline pathogenic variants (PVs) in cancer susceptibility
genes in US Black women compared with non-Hispanic White women with breast cancer is …
genes in US Black women compared with non-Hispanic White women with breast cancer is …
Triple-negative breast cancer risk genes identified by multigene hereditary cancer panel testing
Background Germline genetic testing with hereditary cancer gene panels can identify
women at increased risk of breast cancer. However, those at increased risk of triple-negative …
women at increased risk of breast cancer. However, those at increased risk of triple-negative …
Associations between cancer predisposition testing panel genes and breast cancer
Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
[HTML][HTML] A population-based study of genes previously implicated in breast cancer
C Hu, SN Hart, R Gnanaolivu, H Huang… - … England Journal of …, 2021 - Mass Medical Soc
Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA‐negative Hispanics with …
JN Weitzel, SL Neuhausen, A Adamson, S Tao… - Cancer, 2019 - Wiley Online Library
Background Breast cancer (BC) is the most common cancer and related cause of mortality
among Hispanics, yet susceptibility has been understudied. BRCA1 and BRCA2 (BRCA) …
among Hispanics, yet susceptibility has been understudied. BRCA1 and BRCA2 (BRCA) …
Association of a polygenic risk score with breast cancer among women carriers of high-and moderate-risk breast cancer genes
S Gallagher, E Hughes, S Wagner, P Tshiaba… - JAMA network …, 2020 - jamanetwork.com
Importance To date, few studies have examined the extent to which polygenic single-
nucleotide variation (SNV)(formerly single-nucleotide polymorphism) scores modify risk for …
nucleotide variation (SNV)(formerly single-nucleotide polymorphism) scores modify risk for …
[HTML][HTML] Risk of breast cancer among carriers of pathogenic variants in breast cancer predisposition genes varies by polygenic risk score
PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …
Performance of Breast Cancer Polygenic Risk Scores in 760 Female CHEK2 Germline Mutation Carriers
Background Genome-wide association studies suggest that the combined effects of breast
cancer (BC)-associated single nucleotide polymorphisms (SNPs) can improve BC risk …
cancer (BC)-associated single nucleotide polymorphisms (SNPs) can improve BC risk …