Results of two large case–control studies that analyzed the associations between a number
of putative cancer susceptibility genes and breast cancer risk are now reported in the …

BACKGROUND As panel testing becomes more common in clinical practice, it is important
to understand the prevalence and trends associated with the pathogenic variants (PVs) …

ContextGenetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to
the care of women with a severe family history of breast or ovarian cancer, but an unknown …

Background The risks of breast cancer in African American (AA) women associated with
inherited mutations in breast cancer predisposition genes are not well defined. Thus …

Background There is sparse clinical information on the racial and ethnic distribution of
results of multigene panel testing among individuals at high risk for hereditary cancer …

Background The germline cancer predisposition genes associated with increased risk of
each clinical subtype of breast cancer, defined by estrogen receptor (ER), progesterone …

Multigene panel testing of breast cancer predisposition genes have been extensively
conducted in Europe and America, which is relatively rare in Asia however. In this study, we …

Genetic predisposition testingfor breast cancer and other cancers has become a
cornerstone in the evaluation of women with breast cancer, particularly if their disease is …

Background Although management guidelines exist for several genes associated with a 2‐
fold to 5‐fold increase in the relative risk for certain cancers, the value of testing for them …

Abstract Background Breast cancers (BCs) that arise in individuals heterozygous for a
germline pathogenic variant in a susceptibility gene, such as BRCA1 and BRCA2, PALB2 …