Several “moderate-risk breast cancer susceptibility genes” have been conclusively
identified. Pathogenic mutations in these genes are thought to cause a two to fivefold …

Background Breast cancer has a significant heritable basis, of which∼ 60% remains
unexplained. Testing for BRCA1/BRCA2 offers useful discrimination of breast cancer risk …

Purpose Testing for germline mutations in BRCA1/2 is standard for select patients with
breast cancer to guide clinical management. Next-generation sequencing (NGS) allows …

African American breast cancer genetics is less understood compared to European
American breast cancer susceptibility. Despite the many advantages of gene panel …

Purpose Gene panel sequencing is revolutionizing germline risk assessment for hereditary
breast cancer. Despite scant evidence supporting the role of many of these genes in breast …

Background Concurrent germline (g) pathogenic variants related to hereditary breast cancer
represent a rare occurrence. While double heterozygosity in gBRCA1 and gBRCA2 has …

Inherited pathogenic variants in genes that confer moderate to high risk of breast cancer
may explain up to 50% of familial breast cancer. This study aimed at identifying inherited …

A positive family history is one of the most firmly established risk factors for breast cancer
(BC). Women with at least one firstdegree relative with BC have an 1.8-fold risk to develop …

Between 5 and 10% of breast cancer is attributable to inherited cancer susceptibility genes.
Mutations in the genes BRCA1 and BRCA2 account for two-thirds of hereditary breast …

Background: Breast cancer susceptibility genes such as BRCA1, BRCA2, PALB2, CHEK2
and many others are increasingly recognized among our patient population. In addition to …