ABSTRACT A hereditary predisposition to breast cancer significantly influences screening
and follow-up recommendations for high-risk women. However, in patients with a suggestive …

METHODS Patient and control populations A total of 161 women with breast and at least
one other nonbreast cancer were evaluated. Some 96 patients were recruited from the …

Purpose The contribution of genetic factors to cancer in non-Jewish populations in Israel is
understudied. Yet the early, mostly premenopausal age at breast cancer diagnosis is …

Background While the likelihood of identifying constitutional breast cancer-associated
BRCA1, BRCA2 and TP53 pathogenic variants (PVs) increases with earlier diagnosis age …

Inactivating mutations in 10 different genes in pathways critical to genomic integrity have
been confirmed to be associated with inherited breast cancer in different ethnic groups [1] …

Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to
identify further breast cancer (BC) susceptibility genes. BARD1 (BRCA1-associated ring …

Introduction: We sought to understand the factors associated with recruitment activities while
conducting a registry-based study of black women found to have breast cancer< age 50 to …

ContextTen years after BRCA1 and BRCA2 were first identified as major breast cancer
susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic …

Ethnic differences in cancer incidence and mortality exist and are probably the result of
genetic and epidemiological risk factors. Genetic differences caused by founder mutations …

Disclaimer: This points to consider document is designed primarily as an educational
resource for medical geneticists and other clinicians to help them provide quality medical …