The molecular mechanisms underlying the aging process have garnered much attention in
recent decades because aging is the most significant risk factor for many chronic diseases …

As a tool for measuring the aging process, life span has been invaluable in dissecting the
genes that modulate longevity. Studies over the past few decades have identified several …

Aging is characterized by general physiological decline over time. A hallmark of human
senescence is the onset of various age-related afflictions including neurodegeneration …

Aging research has been very successful at identifying signaling pathways and
evolutionarily conserved genes that extend lifespan with the assumption that an increase in …

Evidence gathered over the past 15 years shows that the nematode Caenorhabditis elegans
is excellently suited as a model to study aging processes in the entire organism. Genetic …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

Background: Numerous gerontogene mutants leading to dramatic life extensions have been
identified in the nematode Caenorhabditis elegans over the last 20 years. Analysis of these …

The antagonistic pleiotropy theory of aging proposes that aging takes place because natural
selection favors genes that confer benefit early on life at the cost of deterioration later in life …

A common property of aging in all animals is that chronologically and genetically identical
individuals age at different rates. To unveil mechanisms that influence aging variability, we …

The nematode Caenorhabditis elegans is used as a model system for the study of aging.
Several mutant strains that have an increased lifespan have been isolated and …