Engineered Treg cells: The heir to the throne of immunotherapy

A Stucchi, F Maspes, E Montee-Rodrigues… - Journal of …, 2023 - Elsevier
Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Opportunities for Treg cell therapy for the treatment of human disease

JA Bluestone, BS McKenzie, J Beilke… - Frontiers in …, 2023 - frontiersin.org
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

[HTML][HTML] Super-Treg: toward a new era of adoptive Treg therapy enabled by genetic modifications

L Amini, J Greig, M Schmueck-Henneresse… - Frontiers in …, 2021 - frontiersin.org
Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis.
Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in …

Treg cell-based therapies: challenges and perspectives

C Raffin, LT Vo, JA Bluestone - Nature Reviews Immunology, 2020 - nature.com
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Treg enhancing therapies to treat autoimmune diseases

PJ Eggenhuizen, BH Ng, JD Ooi - International journal of molecular …, 2020 - mdpi.com
Regulatory T cells (Tregs) are a small yet critical subset of CD4+ T cells, which have the role
of maintaining immune homeostasis by, for example, regulating self-tolerance, tumor …

Harnessing regulatory T cells to establish immune tolerance

P Ho, E Cahir-McFarland, JD Fontenot… - Science Translational …, 2024 - science.org
Engineered regulatory T (Treg) cells have emerged as precision therapeutics aimed at
inducing immune tolerance while reducing the risks associated with generalized …

Treg cells in health and autoimmune diseases: New insights from single cell analysis

C Scheinecker, L Göschl, M Bonelli - Journal of autoimmunity, 2020 - Elsevier
Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

[HTML][HTML] Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation

C Selck, M Dominguez-Villar - Frontiers in immunology, 2021 - frontiersin.org
Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells
whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is …

[HTML][HTML] Therapeutic potential of gene-modified regulatory T cells: from bench to bedside

WJ Chae, ALM Bothwell - Frontiers in Immunology, 2018 - frontiersin.org
Regulatory T cells (Tregs) are an important subset of adaptive immune cells and control
immune reactions for maintaining homeostasis. Tregs are generated upon their encounter …

[PDF][PDF] The potential for Treg-enhancing therapies in transplantation

R Steiner, N Pilat - Clinical and experimental immunology, 2023 - academic.oup.com
Since the discovery of regulatory T cells (Tregs) as crucial regulators of immune tolerance
against self-antigens, these cells have become a promising tool for the induction of donor …