Objectives The main purpose of this study was to assess the role of l-arginine/SNAP/NO/
cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. Methods Male …

As a promising flavonoid, naringenin has shown potential anti-inflammatory and antioxidant
properties mainly in inflammatory pain models by oral administration. Therefore, we …

The literature shows that the monoterpenes are great candidates for the development of new
drugs for the treatment of various pathological processes, including painful conditions. The …

Objective (s): Growing evidence demonstrates that L-arginine/NO/cGMP/K ATP channel
pathway has a modulatory role in pain perception. Previous studies have shown that …

Rosemary essential oil (REO) has been used for several medical purposes. Previous
studies have shown the antinociceptive effect of the oil. This study aimed to investigate the …

Background Several lines of evidence have indicated that nitric oxide (NO) plays complex
and diverse roles in modulation of pain/analgesia. However, the roles of charged and …

One of the main functions of the sensory system in our body is to maintain somatosensory
homeostasis. Recent reports have led to a significant advance in our understanding of pain …

The perception of pain caused by inflammation serves as a warning sign to avoid further
injury. The generation and transmission of pain impulses involves various pathways and …

Substances derived from plants play an important role in the development of new analgesic
drugs, among them, triterpenoids. The connection between the participation of L …

The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-
sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid …