Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer

RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

Cell-penetrating peptides: Applications in tumor diagnosis and therapeutics

J Stiltner, K McCandless, M Zahid - Pharmaceutics, 2021 - mdpi.com
Since their identification over twenty-five years ago, the plethora of cell-penetrating peptides
(CPP) and their applications has skyrocketed. These 5 to 30 amino acid in length peptides …

The role of cell‐penetrating peptides in potential anti‐cancer therapy

M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Cell penetrating peptides for tumor targeting

Y Suk Choi, J Yeon Lee, J Sook Suh… - Current …, 2011 - ingentaconnect.com
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack
of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs …

Cell-penetrating peptides: strategies for anticancer treatment

D Raucher, JS Ryu - Trends in molecular medicine, 2015 - cell.com
Cell-penetrating peptides (CPP) provide an efficient strategy for the intracellular delivery of
bioactive molecules in various biomedical applications. This review focuses on recent …

Cell penetrating peptides: the potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Delivery of various cargos into cancer cells and tissues via cell-penetrating peptides: a review of the last decade

A Shoari, R Tooyserkani, M Tahmasebi, DWPM Löwik - Pharmaceutics, 2021 - mdpi.com
Abstracts Cell-penetrating peptides (CPPs), also known as protein transduction domains,
are a class of diverse amino acid sequences with the ability to cross cellular membranes …

Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules

H Zhang, Y Zhang, C Zhang, H Yu, Y Ma, Z Li, N Shi - Pharmaceutics, 2023 - mdpi.com
Peptides and proteins, two important classes of biomacromolecules, play important roles in
the biopharmaceuticals field. As compared with traditional drugs based on small molecules …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Intelligent substance delivery into cells using cell-penetrating peptides

T Tashima - Bioorganic & Medicinal Chemistry Letters, 2017 - Elsevier
Cell-penetrating peptides (CPPs) are oligopeptides that can permeate the cell membrane.
The use of a CPP-mediated transport system could be an excellent method for delivering …