In this review, a stem cell concept, initially defined by the author more than 10 years ago
focusing on neural stem cells, has been systematically refined and updated. Relative to the …

In this review, we propose an updated concept of the neural stem cell (NSC). New data of
our own and others suggest that the field's conventional view which has touched principally …

Abstract Neural Stem Cells have the cardinal properties of stem cells—the ability to self-
renew and to generate differentiated progeny. They are found broadly throughout the …

Stem cells play a critical role during embryo and tissue formation throughout development.
Thanks to their multipotentiality–ie, the ability to give rise to different lineages of mature cells …

Normal CNS development involves the sequential differentiation of multipotent stem cells.
Alteration of the numbers of stem cells, their self-renewal ability, or their proliferative capacity …

Stem cells derived from adult tissues have long been considered multipotent, able to
differentiate into a limited number of cell types found in their tissue of origin. Embryonic stem …

Stem cells are fascinating cell types. They can replicate themselves forever while retaining
the potential to generate progeny with specific functions. Because of these special …

A current disturbing trend in stem cell biology is the abandonment of rigorous definitions of
stem and progenitor cells in favor of more ambiguous, all-encompassing concepts …

Stem Cells and CNS Development critically reviews recent findings on stem cells, their
involvement in neurogenesis and gliogenesis, and the therapeutic implications of these …

In spite of increasing numbers of publications about cell replacement therapies in various
neurodegenerative diseases, reports on therapeutic benefits are still rare due to the huge …