[HTML][HTML] HGF/c-Met: a key promoter in liver regeneration

Y Zhao, W Ye, YD Wang, WD Chen - Frontiers in pharmacology, 2022 - frontiersin.org
Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on
various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue …

Hepatocyte growth factor in physiology and infectious diseases

R Imamura, K Matsumoto - Cytokine, 2017 - Elsevier
Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-
chain, and these chains contain four kringle domains and a serine protease-like structure …

[HTML][HTML] HGF–Met pathway in regeneration and drug discovery

K Matsumoto, H Funakoshi, H Takahashi, K Sakai - Biomedicines, 2014 - mdpi.com
Hepatocyte growth factor (HGF) is composed of an α-chain and a β-chain, and these chains
contain four kringle domains and a serine protease-like structure, respectively. Activation of …

[PDF][PDF] Hepatocyte growth factor/c‐met signaling is required for stem‐cell–mediated liver regeneration in mice

T Ishikawa, VM Factor, JU Marquardt, C Raggi… - …, 2012 - Wiley Online Library
Hepatocyte growth factor (HGF)/c‐Met supports a pleiotrophic signal transduction pathway
that controls stem cell homeostasis. Here, we directly addressed the role of c‐Met in stem …

Met provides essential signals for liver regeneration

M Borowiak, AN Garratt, T Wüstefeld… - Proceedings of the …, 2004 - National Acad Sciences
Genetic analysis in mice has demonstrated a crucial role of the Met tyrosine kinase receptor
and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver …

Hepatocyte growth factor twenty years on: Much more than a growth factor

T Nakamura, K Sakai, T Nakamura… - Journal of …, 2011 - Wiley Online Library
Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

A Giebeler, MV Boekschoten, C Klein, M Borowiak… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The hepatocyte growth factor (HGF)/mesenchymal-epithelial
transition factor (c-Met) system is an essential inducer of hepatocyte growth and …

The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine

T Nakamura, S Mizuno - Proceedings of the Japan Academy, Series …, 2010 - jstage.jst.go.jp
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes.
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility …

[HTML][HTML] Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals

T Kato - Biomedical reports, 2017 - spandidos-publications.com
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it
stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various …

Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis

S Mizuno, T Nakamura - 2007 - Future Medicine
Liver cirrhosis is a major cause of morbidity worldwide and is characterized by the loss of
hepatocytes with interstitial fibrosis. In this review, we discuss the potential uses of …