Targeting the HGF‐cMET axis in hepatocellular carcinoma

NK Venepalli, L Goff - International journal of hepatology, 2013 - Wiley Online Library
Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor,
the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis …

Enhanced expression of hepatocyte growth factor/c-Met by myocardial ischemia and reperfusion in a rat model

K Ono, A Matsumori, T Shioi, Y Furukawa… - Circulation, 1997 - Am Heart Assoc
Background Hepatocyte growth factor (HGF) is a multifunctional factor implicated in tissue
regeneration, wound healing, and angiogenesis. Circulating HGF is reportedly elevated …

Structure and function of hepatocyte growth factor

T Nakamura - Progress in growth factor research, 1991 - Elsevier
Hepatocyte growth factor (HGF), a potent mitogen for mature hepatocytes in primary culture,
was first found in sera of partial hepatectomized rats and seems to be a hepatotrophic factor …

Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats

Y Matsuda, K Matsumoto, T Ichida… - The journal of …, 1995 - jstage.jst.go.jp
Hepatic fibrosis/cirrhosis is a common hepatic disease characterized by the hyper-ac-
cumulation of connective tissue components, and hepatic necrosis. Chronic alcohol inges …

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

CG Huh, VM Factor, A Sánchez… - Proceedings of the …, 2004 - National Acad Sciences
Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance
during development as well as in tumorigenesis. Because homozygous null mice for either …

[PDF][PDF] Hepatocyte growth factor induces Mcl‐1 in primary human hepatocytes and inhibits CD95‐mediated apoptosis via Akt

H Schulze‐Bergkamen, D Brenner, A Krueger… - …, 2004 - Wiley Online Library
Abstract CD95 (APO‐1/Fas)‐mediated apoptosis of hepatocytes plays a central role in the
pathophysiology of various human liver diseases. Hepatocyte growth factor (HGF) was …

[HTML][HTML] The role of HGF/MET in liver cancer

G Gupta, WH Al-Malki, I Kazmi… - Future medicinal …, 2021 - Future Science
Liver cancer is the sixth most prevalent form of cancer worldwide and the third leading cause
of cancer-related death [1]. Chronic hepatitis due to excessive alcohol intake, autoimmune …

Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration

K MATSUMOTO, T NAKAMURA - Journal of gastroenterology …, 1991 - Wiley Online Library
Hepatocyte growth factor (HGF) is a most potent factor for mature parenchymal hepatocytes
in primary culture and may act as a trigger for liver regeneration. We purified HGF from rat …

Pharmacokinetic study of recombinant human hepatocyte growth factor administered in a bolus intravenously or via portal vein

A Ido, A Moriuchi, I Kim, M Numata… - Hepatology …, 2004 - Elsevier
Hepatocyte growth factor (HGF) stimulates liver regeneration and has the potential to be a
therapeutic agent for fatal liver diseases, including fulminant hepatic failure and liver …

[PDF][PDF] c‐Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma

H You, W Ding, H Dang, Y Jiang, CB Rountree - Hepatology, 2011 - Wiley Online Library
Abstract c‐Met, a high‐affinity receptor for hepatocyte growth factor (HGF), plays a critical
role in cancer growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients …