Expression of hepatocyte growth factor (HGF) and HGF receptor (c‐met) proteins in liver diseases: an immunohistochemical study

J Okano, G Shiota, H Kawasaki - Liver, 1999 - Wiley Online Library
Background: Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes in vivo as
well as in vitro. Serum levels of HGF vary in liver diseases, reflecting liver damage and …

Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with …

N Horiguchi, H Takayama, M Toyoda, T Otsuka… - Oncogene, 2002 - nature.com
Hepatocyte growth factor (HGF) is a mitogen for hepatocytes, but it is not clear whether HGF
stimulates or inhibits hepatocarcinogenesis. We previously reported that HGF transgenic …

[HTML][HTML] Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases

K Matsumoto, T Nakamura - Kidney international, 2001 - Elsevier
Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases.
Hepatocyte growth factor (HGF), a ligand for the c-Met receptor tyrosine kinase, has …

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

K Matsumoto, T Nakamura - Critical reviews in oncogenesis, 1992 - europepmc.org
Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and
seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF …

Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways

OO Ogunwobi, C Liu - Clinical & experimental metastasis, 2011 - Springer
Advanced hepatocellular carcinoma (HCC) is an important cause of cancer mortality.
Epithelial-mesenchymal transition (EMT) has been shown to be an important biological …

[HTML][HTML] Up-regulation of hepatocyte growth factor receptor: an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure

Y Liu, EM Tolbert, L Lin, MA Thursby, AM Sun… - Kidney international, 1999 - Elsevier
Up-regulation of hepatocyte growth factor receptor: An amplification and targeting
mechanism for hepatocyte growth factor action in acute renal failure. Background …

HGF: its organotrophic role and therapeutic potential

K Matsumoto, T Nakamura - Ciba Foundation Symposium 212 …, 2007 - Wiley Online Library
Hepatocyte growth factor (HGF), originally implicated as a long‐sought after hepatotrophic
factor, supports epithelial branching duct formation in the developing lung as a …

Emerging multipotent aspects of hepatocyte growth factor

K Matsumoto, T Nakamura - The journal of biochemistry, 1996 - academic.oup.com
Specific tissue interactions between epithelia and mesenchyme (or stroma), eg, epithelial-
mesenchymal (or-stromal) interactions mediate crucial aspects of normal development and …

[HTML][HTML] The function of the HGF/c-Met axis in hepatocellular carcinoma

H Wang, B Rao, J Lou, J Li, Z Liu, A Li, G Cui… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …

[HTML][HTML] HGF/c-MET axis in tumor microenvironment and metastasis formation

A Spina, V De Pasquale, G Cerulo, P Cocchiaro… - Biomedicines, 2015 - mdpi.com
Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Metastasis formation is a multistep process that requires acquisition by tumor cells of a …