Hepatocyte growth factor (HGF) is a multifunctional growth factor affecting cell proliferation
and differentiation. Due to its mitogenic potential, HGF plays an important role in tubular …

Liver is unique in its capacity to regenerate in response to injury or tissue loss. Hepatocytes
and other liver cells are able to proliferate and repopulate the liver. However, when this …

Hepatocyte growth factor (HGF) is a potent paracrine mediator of stromal/epithelial
interactions, which is secreted as a matrix-associated inactive precursor (pro-HGF) and …

Liver regeneration is known to be a process involving highly organized and ordered tissue
growth triggered by the loss of liver tissue, and remains a fascinating topic. A large number …

Cholestasis, an impairment of bile outflux, frequently occurs in liver diseases. In this process,
an overaccumulation of bile acids causes hepatocyte necrosis and apoptosis, leading to …

Receptor tyrosine kinases have become important therapeutic targets for anti-neoplastic
molecularly targeted therapies. c-Met is a receptor tyrosine kinase shown to be over …

Hepatocyte growth factor (HGF), a pleiotropic cytokine of mesenchymal origin promoting
migration, proliferation, and survival in a wide spectrum of cells, can also modulate different …

Hepatocyte growth factor (HGF) and its specific c-met receptor constitute a paired signaling
system that plays an important role in renal development and in the maintenance of normal …

Receptor tyrosine kinases have come to fruition as therapeutic targets in a variety of
malignancies. In this group of targets, the c-Met receptor tyrosine kinase plays an important …

Hepatocyte growth factor (HGF) has been shown to be indispensable for liver regeneration
because it serves as a main mitogenic stimulus driving hepatocytes toward proliferation. We …