Hepatocyte growth factor (HGF) was originally isolated as a mitogen for adult hepatocytes,
but this cytokine is now regarded as a multi-functional factor. In the present study, we show …

The poor prognosis of hepatocellular carcinoma (HCC), one of the most devastating cancers
worldwide, is due to frequent recurrence and metastasis. Among the metastatic factors in the …

Hepatocyte growth factor (HGF) has been discovered, purified, and molecularly cloned as a
potent mitogen for mature hepatocytes. HGF is a heterodimeric molecule composed of a 69 …

Hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met
tyrosine kinase, drives mitogenesis, motogenesis and morphogenesis in a wide spectrum of …

Hepatocyte growth factor (HGF), a humoral mediator for regeneration of liver and kidney,
possesses multiple biological activities. To investigate target cell specificity and to examine …

Liver regeneration is a highly organized tissue regrowth process and is the most important
reaction of the liver to injury. The overall process of liver regeneration includes three phases …

MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepatocyte
growth factor (HGF) receptor, a member of the receptor tyrosine kinase (RTK) family. HGF …

Hepatocyte growth factor (HGF) and its receptor, Met, regulate a number of biological
functions in epithelial and nonepithelial cells, such as survival, motility, proliferation, and …

The two papers in this issue of Hepatology (1, 2) dealing with hepatocyte growth factor
(HGF) underscore the increasing importance of this novel growth factor in relation to hepatic …

Hepatocyte growth factor (HGF) and transforming growth factor α (TGF‐α) stimulate liver
regeneration, whereas transforming growth factor β 1 (TGF‐β 1) inhibits it in rats. However …