HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence

J Fu, X Su, Z Li, L Deng, X Liu, X Feng, J Peng - Oncogene, 2021 - nature.com
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

[HTML][HTML] Targeting the hepatocyte growth factor–cMET axis in cancer therapy

GR Blumenschein Jr, GB Mills… - Journal of clinical …, 2012 - ncbi.nlm.nih.gov
The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …

C-MET as a new therapeutic target for the development of novel anticancer drugs

I Canadas, F Rojo, M Arumí-Uría, A Rovira… - Clinical and …, 2010 - Springer
MET is a tyrosine kinase receptor that, upon binding of its natural ligand, the hepatocyte
growth factor (HGF), is phosphorylated and subsequently activates different signalling …

[HTML][HTML] Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis

LE Gomez-Quiroz, VM Factor, P Kaposi-Novak… - Journal of biological …, 2008 - ASBMB
The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction
pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met …

Expression of HGF, Its Receptor c-met, c-myc, and Albumin in Cirrhotic and Neoplastic Human Liver Tissue

JY Ljubimova, LM Petrovic, SE Wilson… - … of Histochemistry & …, 1997 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is a common type of cancer, with approximately 260,000
new cases each year, and liver cirrhosis is generally considered a major predisposing factor …

Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells

TE Kmiecik, JR Keller, E Rosen, GF Vande Woude - 1992 - ashpublications.org
Bone marrow (BM) stromal cells, which include macrophages, fibroblasts, endothelial cells,
and adipocytes, have been shown to produce several factors that modulate the growth of BM …

Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma.

S Osada, M Kanematsu, H Imai… - Hepato …, 2008 - europepmc.org
Results Firstly, the serum HGF levels were significantly higher in invasive gross type or in IM-
positive tumors. Secondly, the mean expression value of HGF protein in tumors was 0.56+ …

Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference

S Paranjpe, WC Bowen, AW Bell, K Nejak-Bowen… - Hepatology, 2007 - journals.lww.com
Hepatocyte growth factor (HGF) and its receptor c-Met are involved in liver regeneration. The
role of HGF and c-Met in liver regeneration in rat following two-thirds partial hepatectomy …

Cellular and molecular mechanisms of HGF/Met in the cardiovascular system

S Gallo, V Sala, S Gatti, T Crepaldi - Clinical science, 2015 - portlandpress.com
Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor)
receptor. The HGF/Met pathway has a prominent role in cardiovascular remodelling after …

[HTML][HTML] Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in Met binding and signaling

D Kirchhofer, X Yao, M Peek, C Eigenbrot… - Journal of Biological …, 2004 - ASBMB
Hepatocyte growth factor (HGF), a plasminogen-related growth factor, is the ligand for Met, a
receptor tyrosine kinase implicated in development, tissue regeneration, and invasive tumor …