Background: Scleroderma is a heterogeneous group of diseases that can be localized or
systemic. Localized scleroderma is a fibrosis of the skin characterized by inflammation and …

Background: The management of systemic sclerosis remains unsatisfactory. Thus far, the
action of extracorporeal photopheresis (ECP) in severe systemic scleroderma has been …

Abstract Systemic sclerosis (scleroderma)(SSc) is a rare autoimmune disorder characterized
by excessive production of collagen. Extracorporeal photopheresis (photochemotherapy …

BACKGROUND: Systemic sclerosis is a multisystemic connective tissue disease with
marked involvement of the skin and joints for which few effective evidence based therapies …

Abstract Purpose of Review Extracorporeal photochemotherapy (photopheresis, ECP) is a
cell-based immunomodulatory treatment that separates leukocytes from peripheral blood …

Background: Effective treatment modalities for systemic sclerosis, a life-threatening and
disabling disease, are still lacking. Possible efficacy of photopheresis has been reported in …

Background: Extracorporeal photochemotherapy (EP) is a new immune-modulating therapy
which combines cytapheresis and extracorporeal irradiation of leukocytes by UVA. Recently …

Background Extracorporeal photochemotherapy (photopheresis), an immune‐modulating
therapy, has been demonstrated to elicit a therapeutic response in the treatment of several …

Systemic and localized scleroderma are difficult to manage diseases with no accepted gold
standard of therapy to date. Phototherapeutic modalities for scleroderma show promise. A …

Background Extracorporeal photopheresis (ECP) has been considered for treatment of
patients with systemic sclerosis (SSc). Objectives To study the 12-month effects of ECP on …