Epigenetic modifications modulate conformational structure of chromatin and consequently
gene expression by enzyme-mediated chemical modifications of DNA and histones. The …

Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

The harmful consequences of carcinogenic metals, such as nickel, arsenic, and chromium,
are thought to be in part due to their ability to induce oxidative stress. The ubiquity of …

Reactive oxygen species (ROS) cause alterations in the cellular redox status (GSH/GSSG
ratio) and hence activate various kinase signaling pathways, redox sensitive transcription …

Histone post-translational modifications regulate transcription and other DNA-templated
functions. This process is dynamically regulated by specific modifying enzymes whose …

Epigenetics is defined as the mitotically/meiotically heritable changes in gene expression
that are not due to changes in the primary DNA sequence. Over recent years, growing …

Epigenetic modifications, including those on DNA and histones, have been shown to
regulate cellular metabolism by controlling expression of enzymes involved in the …

Environmental exposure to heavy metals poses significant threats to human health as they
are associated with various developmental and chronic pathologies such as reproductive …

Cells are continuously subjected to an array of reactive/toxic chemical species which are
produced both endogenously through metabolic pathways and taken up exogenously by …

Epigenetic regulation of gene expression provides a finely tuned response capacity for cells
when undergoing environmental changes. However, in the context of human physiology or …