The neural circuits of innate fear: detection, integration, action, and memorization

BA Silva, CT Gross, J Gräff - Learning & memory, 2016 - learnmem.cshlp.org
How fear is represented in the brain has generated a lot of research attention, not only
because fear increases the chances for survival when appropriately expressed but also …

Neurobiological advances of learned fear in humans

S Battaglia - Advances in Clinical and Experimental Medicine, 2022 - cris.unibo.it
In the whole animal kingdom, fear learning is an essential process that allows living beings
to survive. Therefore, revealing the neurophysiological processes that govern the …

Overlapping neural systems mediating extinction, reversal and regulation of fear

D Schiller, MR Delgado - Trends in cognitive sciences, 2010 - cell.com
Learned fear is a process allowing quick detection of associations between cues in the
environment and prediction of imminent threat. Adaptive function in a changing environment …

Neurobiology of fear and specific phobias

R Garcia - Learning & memory, 2017 - learnmem.cshlp.org
Fear, which can be expressed innately or after conditioning, is triggered when a danger or a
stimulus predicting immediate danger is perceived. Its role is to prepare the body to face this …

Neuronal circuits for fear and anxiety

P Tovote, JP Fadok, A Lüthi - Nature Reviews Neuroscience, 2015 - nature.com
Decades of research has identified the brain areas that are involved in fear, fear extinction,
anxiety and related defensive behaviours. Newly developed genetic and viral tools …

The neurobiology of fear generalization

A Asok, ER Kandel, JB Rayman - Frontiers in behavioral …, 2019 - frontiersin.org
The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …

Proximal threats promote enhanced acquisition and persistence of reactive fear-learning circuits

L Faul, D Stjepanović, JM Stivers… - Proceedings of the …, 2020 - National Acad Sciences
Physical proximity to a traumatic event increases the severity of accompanying stress
symptoms, an effect that is reminiscent of evolutionarily configured fear responses based on …

The amygdala and medial prefrontal cortex: partners in the fear circuit

R Marek, C Strobel, TW Bredy… - The Journal of physiology, 2013 - Wiley Online Library
Fear conditioning and fear extinction are Pavlovian conditioning paradigms extensively
used to study the mechanisms that underlie learning and memory formation. The neural …

[HTML][HTML] A translational perspective on neural circuits of fear extinction: Current promises and challenges

D Sevenster, RM Visser, R D'Hooge - Neurobiology of Learning and …, 2018 - Elsevier
Fear extinction is the well-known process of fear reduction through repeated re-exposure to
a feared stimulus without the aversive outcome. The last two decades have witnessed a …

Coming to terms with fear

JE LeDoux - Proceedings of the National Academy of …, 2014 - National Acad Sciences
The brain mechanisms of fear have been studied extensively using Pavlovian fear
conditioning, a procedure that allows exploration of how the brain learns about and later …