Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

R Guérillot, X Kostoulias, L Donovan… - Proceedings of the …, 2019 - National Acad Sciences
Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic
and persistent infections despite active antibiotic treatment. The molecular basis for this …

[HTML][HTML] Persistence of Staphylococcus aureus: multiple metabolic pathways impact the expression of virulence factors in small-colony variants (SCVs)

L Tuchscherr, B Löffler, RA Proctor - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus is able to survive within host cells by switching its phenotype to the
small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the …

Staphylococcus aureus Small-Colony Variants Are Adapted Phenotypes for Intracellular Persistence

L Tuchscherr, V Heitmann, M Hussain… - The Journal of …, 2010 - academic.oup.com
Background. Staphylococcus aureus is an important human pathogen of endovascular
diseases, which can take a chronic course with a high relapse rate despite antimicrobial …

Large tandem chromosome expansions facilitate niche adaptation during persistent infection with drug-resistant Staphylococcus aureus

W Gao, IR Monk, NJ Tobias… - Microbial …, 2015 - microbiologyresearch.org
We used genomics to study the evolution of meticillin-resistant Staphylococcus aureus
(MRSA) during a complex, protracted clinical infection. Preparing closed MRSA genomes …

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

L Tuchscherr, E Medina, M Hussain… - EMBO molecular …, 2011 - embopress.org
Staphylococcus aureus is a frequent cause for serious, chronic and therapy‐refractive
infections in spite of susceptibility to antibiotics in vitro. In chronic infections, altered bacterial …

A full genomic characterization of the development of a stable small colony variant cell-type by a clinical Staphylococcus aureus strain

LMG Bui, SP Kidd - Infection, Genetics and Evolution, 2015 - Elsevier
A key to persistent and recurrent Staphylococcus aureus infections is its ability to adapt to
diverse and toxic conditions. This ability includes a switch into a biofilm or to the quasi …

Return of the Trojan horse: intracellular phenotype switching and immune evasion by Staphylococcus aureus

C Garzoni, WL Kelley - EMBO molecular medicine, 2011 - embopress.org
Staphylococcus aureus small colony variants (SCVs), which are characterized by slow
growth and a range of morphological and metabolic changes including altered antibiotic …

Phenotype switching is a natural consequence of Staphylococcus aureus replication

AM Edwards - Journal of bacteriology, 2012 - Am Soc Microbiol
The pathogen Staphylococcus aureus undergoes phenotype switching in vivo from its
normal colony phenotype (NCP) to a slow-growing, antibiotic-resistant small-colony-variant …

[HTML][HTML] Novel research models for Staphylococcus aureus small colony variants (SCV) development: co-pathogenesis and growth rate

J Lee, PS Zilm, SP Kidd - Frontiers in Microbiology, 2020 - frontiersin.org
Staphylococcus aureus remains a great burden on the healthcare system. Despite
prescribed treatments often seemingly to be successful, S. aureus can survive and cause a …

Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

SG Giulieri, SL Baines, R Guerillot, T Seemann… - Genome medicine, 2018 - Springer
Background Large-scale genomic studies of within-host diversity in Staphylococcus aureus
bacteraemia (SAB) are needed to understanding bacterial adaptation underlying …