Pathogenesis of myocardial fibrosis in spontaneously hypertensive rats (SHR)

HJ Herrmann, U Fiedler, R Blödner - European heart journal, 1995 - academic.oup.com
The pathomechanisms of myocardial fibrosis are incompletely understood. Coronary
microvessels (MV), interstitial reactions and focal myocardial lesions characterized by …

Advanced hypertensive heart disease in spontaneously hypertensive rats: lisinopril-mediated regression of myocardial fibrosis

CG Brilla, L Matsubara, KT Weber - Hypertension, 1996 - Am Heart Assoc
Left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR) is
accompanied by a structural remodeling of the myocardium that includes myocyte …

Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat

CH Conrad, WW Brooks, JA Hayes, S Sen… - Circulation, 1995 - Am Heart Assoc
Background Fibrosis is commonly found in association with cardiac hypertrophy and failure,
but the relation of the connective tissue response to the development of impaired cardiac …

Causative role of coronary microvessels for the development and progression of chronic myocardial lesions in spontaneously hypertensive rats (SHR)

HJ Herrmann, P Mühlig - Basic research in cardiology, 1992 - Springer
The pathomechanisms responsible for the development and progression of myocardial
alterations in hypertensive heart disease are largely unknown. Using newly developed …

Colocalization of myocardial fibrosis and inflammatory cells in rats.

N Hinglais, D Heudes, A Nicoletti, C Mandet… - … ; a Journal of …, 1994 - europepmc.org
Colocalization of myocardial fibrosis and inflammatory cells in rats. - Abstract - Europe PMC
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Reactive and reparative myocardial fibrosis in arterial hypertension in the rat

CG Brilla, KT Weber - Cardiovascular research, 1992 - academic.oup.com
Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two
experimental models of arterial hypertension the purpose of the study was (a) to determine …

Myocardial fibrosis in hypertensive heart disease: an overview of potential regulatory machanisms

KT Weber, Y Sun, E Guarda, LC Katwa… - European heart …, 1995 - academic.oup.com
Myocardial fibrosis in hypertensive heart disease (HHD) can present as a reactive process,
involving intramyocardial coronary arteries and arterioles with extensions of collagen into …

Mechanisms of cardiac fibrosis in hypertension

J Díez - The Journal of Clinical Hypertension, 2007 - Wiley Online Library
Changes in the composition of cardiac tissue develop in hypertensive patients with left
ventricular hypertrophy (ie, hypertensive heart disease) and lead to structural remodeling of …

Myocardial fibrosis rather than hypertrophy induces diastolic dysfunction in renovascular hypertensive rats

LS Matsubara, BB Matsubara… - Canadian journal of …, 1997 - cdnsciencepub.com
The aim of the present study was to evaluate the effect of interstitial fibrosis alone or
associated with hypertrophy on diastolic myocardial function in renovascular hypertensive …

Left ventricular fibrosis in renovascular hypertensive rats: effect of losartan and spironolactone

A Nicoletti, D Heudes, N Hinglais, MD Appay… - …, 1995 - Am Heart Assoc
Myocardial fibrosis resulting from arterial hypertension alters myocardial structure and
function. Myocardial fibrosis is characterized by a pathological accumulation of types I and III …