Foxp3+ regulatory T cells (Tregs) represent a special lineage of CD4+ T cells. Analysis of
Treg response during primary and secondary influenza virus infection clearly demonstrates …

FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets:
naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) …

Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are
key to maintenance of immune homeostasis. Over the past decade, Treg cells have become …

Helios, a member of the Ikaros transcription factor family, is preferentially expressed at the
mRNA level by regulatory T cells (Treg cells). We evaluated Helios protein expression using …

Abstract Regulatory Foxp3+ CD4 T cells (Tregs) prevent spontaneous inflammation in the
lungs, inhibit allergic and asthmatic responses, and contribute to tolerance to inhaled …

ABSTRACT Foxp3+ CD4+ regulatory T cells (Tregs) represent a highly suppressive T cell
subset with well-characterized immunosuppressive effects during immune homeostasis and …

Two distinct subsets of CD4+ Foxp3+ regulatory T (Treg) cells have been described based
on the differential expression of Helios, a transcription factor of the Ikaros family. Efforts to …

We examined the formation, participation, and functional specialization of virus-reactive
Foxp3+ regulatory T cells (Tregs) in a mouse model of influenza virus infection.“Natural” …

(Tregs) express the transcription factor Helios. Interestingly, they found that Foxp3+ cells
generated in the thymus all coexpressed Helios, whereas Tregs generated in vitro from …

During infections, the timings of effector differentiation of pulmonary immune responses are
of paramount importance, as pathogen persistence and unsuppressed inflammation can …