[HTML][HTML] Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease

X Peng, X Zhang, Z Xu, L Li, X Mo, Z Peng, Z Shan… - Ebiomedicine, 2024 - thelancet.com
Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent risk factor for cognitive
impairment. Cerebral amyloid-β (Aβ) accumulation, as an important pathology of cognitive …

[HTML][HTML] Sex-specific relationship between non-alcoholic fatty liver disease and amyloid-β in cognitively unimpaired individuals

SH Kang, H Yoo, BK Cheon, JP Kim, H Jang… - Frontiers in Aging …, 2023 - frontiersin.org
Background: Non-alcoholic fatty liver disease (NAFLD) is known to be associated with a
high risk of clinically diagnosed Alzheimer's disease (AD). Additionally, the prevalence of …

[HTML][HTML] Liver dysfunction as a novel player in Alzheimer's progression: looking outside the brain

LD Estrada, P Ahumada, D Cabrera… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease (AD) afflicts an estimated 20 million people worldwide and is the fourth-
leading cause of death in the developed world. The most common cause of dementia in …

[HTML][HTML] Non-alcoholic fatty liver disease induces signs of Alzheimer's disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

DG Kim, A Krenz, LE Toussaint, KJ Maurer… - Journal of …, 2016 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease afflicting
about one third of the world's population and 30% of the US population. It is induced by …

[HTML][HTML] Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and …

J Garcia, R Chang, RA Steinberg, A Arce… - Frontiers in …, 2022 - frontiersin.org
Heavy alcohol consumption is a known risk factor for various forms of dementia and the
development of Alzheimer's disease (AD). In this work, we investigated how intragastric …

Emerging links between nonalcoholic fatty liver disease and neurodegeneration

TJ Kelty, RJ Dashek, WD Arnold… - Seminars in Liver …, 2023 - thieme-connect.com
The association between liver and brain health has gained attention as biomarkers of liver
function have been revealed to predict neurodegeneration. The liver is a central regulator in …

[HTML][HTML] Non-alcoholic fatty liver disease, and the underlying altered fatty acid metabolism, reveals brain hypoperfusion and contributes to the cognitive decline in APP …

A Pinçon, O De Montgolfier, N Akkoyunlu, C Daneault… - Metabolites, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease, is
associated with cognitive decline in middle-aged adults, but the mechanisms underlying this …

[PDF][PDF] High‐Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease

CR Bosoi, M Vandal, M Tournissac… - Hepatology …, 2021 - Wiley Online Library
Obesity and diabetes are strongly associated not only with fatty liver but also cognitive
dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for …

[HTML][HTML] Associations between non-alcoholic fatty liver disease and cognitive impairment and the effect modification of inflammation

S Kang, E Kim, H Cho, DJ Kim, HC Kim, SJ Jung - Scientific reports, 2022 - nature.com
This study aimed to evaluate the association between non-alcoholic fatty liver disease
(NAFLD) and cognitive impairment and explore the effect modification by the inflammatory …

[HTML][HTML] Risk of dementia or cognitive impairment in non-alcoholic fatty liver disease: a systematic review and meta-analysis

L Wang, B Sang, Z Zheng - Frontiers in aging neuroscience, 2022 - frontiersin.org
Objectives To investigate whether non-alcoholic fatty liver disease (NAFLD) increases the
risk of dementia or cognitive impairment. Methods A systematic search of the literature in the …