Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to
as immunosurveillance. However, multiple inhibitory mechanisms within the tumor …

Lysophospholipids have emerged as biologically important chemoattractants capable of
directing lymphocyte development, trafficking, and localization. Lysophosphatidic acid (LPA) …

Increasing evidence supports roles for lipids in the biology of immune cells. In particular,
bioactive lipids such as sphingosine-1-phosphate (S1P) bind to cognate G protein-coupled …

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid present in low concentrations
in serum and biological fluids but in high concentrations at sites of inflammation. LPA evokes …

Cancer and chronic infections often increase levels of the bioactive lipid, lysophosphatidic
acid (LPA), that we have demonstrated acts as an inhibitory ligand upon binding LPAR5 on …

Negative regulation of innate immune responses is essential to prevent excess inflammation
and tissue injury and promote homeostasis. Lysophosphatidic acid (LPA) is a pleiotropic …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Lysophospholipids (LPLs) are lipid‐derived signaling molecules exemplified by
lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P). Originally identified as …

Among the family of lipid-derived mediators, the group of lysophospholipids including
lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have growth-related and …