Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome
integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we …

DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability.
The capacity of hybrids at different genomic sites to cause DNA damage was not known, and …

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is
crucial for cell viability and genome integrity. The readout of DSB repair may depend on …

Genome instability, a hallmark of cancer progression, is thought to arise through DNA
double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs …

Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA …

The recent discovery of DNA: RNA hybrids, or R-loops, actively forming at DNA double-
strand breaks (DSBs) has unlocked fresh insight into how RNA participates in DNA repair …

DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to
ionizing radiation or replication fork collapse that can lead to genomic instability and cancer …

Although R loops can occur at different genomic locations, the factors that determine their
formation and frequency remain unclear. Emerging evidence indicates that DNA breaks …

RNA-DNA hybrids are a major internal cause of DNA damage within cells, and their
degradation by RNase H enzymes is important for maintaining genomic stability. Here, we …

DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non …