Healthy cells experience thousands of DNA lesions per day during normal cellular
metabolism, and ionizing radiation and chemotherapeutic drugs rely on DNA damage to kill …

DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to
maintain genome stability. DSB resection generates a single strand DNA intermediate …

DNA double strand breaks (DSBs) in repetitive sequences are a potent source of genomic
instability, owing to the possibility of non-allelic homologous recombination (NAHR) …

DNA interstrand crosslinks (ICL) present a major threat to cell viability and genome integrity.
In eukaryotic cells, the ICLs have been suggested to be repaired by a complex process …

Background RNA: DNA hybrids represent a non-canonical nucleic acid structure that has
been associated with a range of human diseases and potential transcriptional regulatory …

It is emerging that the pathways that process newly transcribed RNA molecules also
regulate the response to DNA damage at multiple levels. Here, we discuss recent insights …

Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

Accumulating evidence suggests participation of RNA-binding proteins with intrinsically
disordered domains (IDPs) in the DNA damage response (DDR). These IDPs form liquid …

Genome integrity relies on precise coordination between DNA replication and chromosome
segregation. Whereas replication stress attracted much attention, the consequences of …

A DNA double-strand break (DSB) has long been recognized as a severe cellular lesion,
potentially representing an initiating event for carcinogenesis or cell death. The evolution of …