Background & Aims SLC26A3 (DRA) is an electroneutral Cl-/HCO 3-exchanger that is
present in the apical domain of multiple intestinal segments. An area that has continued to …

Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …

DRA (down regulated in adenoma) is an intestinal anion exchanger, acting in parallel with
NHE3 to facilitate ileal and colonic NaCl absorption. Furthermore it is involved in small …

The recent proposal that Dra/Slc26a3 mediates electrogenic 2Cl−/1HCO3− exchange
suggests a required revision of classical concepts of electroneutral Cl− transport across …

BACKGROUND & AIMS:: Duodenal bicarbonate secretion is in part mediated by an apical
Cl−/HCO3− exchanger of unknown molecular nature. The recently discovered dra (down …

SLC26A3 (downregulated in adenoma; DRA) is a Cl–/anion exchanger expressed in the
luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl …

SLC26A3, or downregulated in adenoma (DRA), plays a major role in mediating Cl−
absorption in the mammalian intestine. Disturbances in DRA function and expression have …

Inorganic sulfate (SO42−) is essential for a multitude of physiological processes. The
specific molecular pathway has been identified for uptake from the small intestine but is …

Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …

HCO 3− secretion is the most important defense mechanism against acid injury in the
duodenum. However, the identity of the transporter (s) mediating apical HCO 3− secretion in …